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Borneol: A Promising Monoterpenoid in Enhancing Drug Delivery Across Various Physiological Barriers 7/5/2024
Borneol: A Promising Monoterpenoid in Enhancing Drug Delivery Across Various Physiological Barriers Abstract: Incorporation of permeation enhancers is a widely employed approach for delivering drugs across biological membranes. Get more news about 2 borneol,you can vist our website! These enhancers aid in overcoming physiological barriers such as brain capillary endothelium, stratum corneum, corneal epithelium, and mucosal membranes that resist the entry of many drugs. Borneol, a natural, plant-derived, lipophilic, volatile, bicyclic monoterpenoid, has been used in Traditional Chinese Medicine (TCM) for over 1000 years under the names “Bing Pian” or “Long Nao.” It has been predominantly incorporated as an adjuvant in TCM formulations of centrally acting drugs to improve drug delivery to the brain. Research has established borneol as a permeation enhancer across the blood-brain barrier (BBB). Alterations in cell membrane lipid structures and modulation of ATP binding cassette transporters and tight junction proteins contribute to borneol’s blood-brain barrier opening functions. Additionally, borneol shows promising potential to improve drug delivery across other physiological barriers, including nasal and gastrointestinal linings, transdermal, transcorneal, and blood optic nerve barriers1. Key Points: Borneol is a naturally occurring compound used in TCM to facilitate the transport of co-administered drugs. It enhances drug delivery across the BBB and other physiological barriers. Mechanisms include altering membrane properties and modulating transporters and tight junction proteins.
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